Twigacycline 20%

Twigacycline 20% is a long-acting, broad-spectrum veterinary antibiotic injection containing 200mg/ml of Oxytetracycline. It treats bacterial infections in cattle, sheep, goats, and pigs, including pneumonia, foot rot, and scours.

Oxytetracycline belongs to the group of tetracyclines and acts bacteriostatic against many Gram-positive and Gram-negative bacteria like Bordetella, Campylobacter, Chlamydia, E. coli, Haemophilus, Mycoplasma, Pasteurella, Rickettsia, Salmonella, Staphylococcus and Streptococcus spp.

The action of oxytetracycline is based on inhibition of bacterial protein synthesis. Oxytetracycline is mainly excreted in urine, for a small part in bile and in lactating animals in milk.

Composition
Each ml of Twigacycline 20% LA Injection contains:

• Active Ingredient: 200 mg of Oxytetracycline (as Oxytetracycline Dihydrate).
• Formulation: 20% w/v long-acting solution for injection.

Contraindications & Side Effects

• Do not use in cats, dogs, horses, or animals with severe renal/liver impairment.
• Avoid concurrent use with penicillins, cephalosporins, or quinolones.
• Side Effects: Potential local reaction at injection site and tooth discoloration in young animals.

Dosage and Administration

• Method: Single, deep intramuscular injection.
• Dosage:20mg/Kg(1mL per 10Kg bodyweight)
• Site Limits: 20mL (cattle), 10mL (pigs), 5mL (sheep/goats).

Withdrawal Periods

• Meat: 28 days.
• Milk: 7 days.

Side Effects

• Local Reactions: Intramuscular administration may cause temporary swelling or irritation at the injection site, which typically disappears in a few days.
• Hypersensitivity: Reactions can occur in some animals.
• Tooth Discoloration: Use in young animals can cause permanent discoloration of teeth.
• Debility: General toxicity is low, but collapse has been reported in weak or debilitated animals.