Biogenta contains Amoxicillin trihydrate 150 mg/ml and Gentamicin 40 mg/ml. It is used for treating bacterial infections in livestock, particularly respiratory and gastrointestinal tract infections.
Each ml contains 150mg Amoxicillin trihydrate and 40mg Gebtamicin base. Indicated for treatment of GIT, Respiratory and intramammary infections in cattle and swine.
The combination of amoxicillin and gentamicin has synergistical action against a wide range of infections caused by both Gram-positive (e.g. Staphylococcus spp., Streptococcus spp. and Corynebacterium spp.) and Gram-negative (e.g. E.coli, Pasteurella spp., Salmonella spp. and Pseudomonas spp.) bacteria in cattle and swine.
Amoxicillin inhibits mainly in Gram-positive bacteria the cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall. Gentamicin binds to the 30S subunit of the ribosome of mainly Gram-negative bacteria, thereby interrupting protein synthesis. Excretion of Biogenta occurs mainly unchanged via urine, and to a lesser degree via milk.
Composition
- Contains per ml:
- Amoxicillin trihydrate 150 mg
- Gentamicin (as sulfate) 40 mg
Indications
- Cattle: gastrointestinal, respiratory and intramammary infections caused by bacteria sensitive to the combination of amoxicillin and gentamicin, such as pneumonia, diarrhoea, bacterial enteritis, mastitis, metritis and cutaneous abscesses.
- Swine: respiratory and gastrointestinal infections caused by bacteria sensitive to the combination of amoxicillin and gentamicin, such as pneumonia, colibacillosis, diarrhoea, bacterial enteritis and mastitis-metritis-agalactia syndrome (MMA).
Contraindications
Hypersensitivity towards amoxicillin or gentamicin. Administration to animals with a seriously impaired hepatic and/or renal function. Concurrent administration of tetracyclines, chloramphenicol, macrolides and lincosamides. Concurrent administration of nephrotoxic compounds.
Side Effects
Hypersensitivity reactions.
Dosage
For intramuscular administration.
- The general dosage is 1 ml per 10 kg body weight per day for 3 days.
- The general dosage is 1 ml per 10 kg body weight per day for 3 days.
- Cattle: 30 - 40 ml per animal per day for 3 days.
- Calves: 10 - 15 ml per animal per day for 3 days.
- Swine: 5 - 10 ml per animal per day for 3 days.
- Piglets: 1 - 5 ml per animal per day for 3 days. Shake well before use.
Do not administer more than 20 ml in cattle or more than 5 ml in calves and more than 10 ml in swine per injection site to favour absorption and dispersion.
Withdrawal Times
- For meat: 30 days.
- For milk: 2 days.
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