Tylosin is a macrolide antibiotic indicated for the treatment of infections caused by bacteria & mycoplasma that are susceptible to tylosin.
Commonly utilized in veterinary medicine to treat susceptible bacterial and mycoplasmal infections. It is widely prescribed to manage respiratory and gastrointestinal diseases in livestock and companion animals.
It is formulated in:
- Tylosin Base: A lipophilic form that crosses tissue membranes easily, making it the preferred choice for injectable solutions, such as those treating respiratory and soft tissue infections in livestock.
- Tylosin Tartrate: A highly water-soluble salt, commonly used for oral administration, feed additives, or in-water medication.
Mode of action:
Tylosin is a bacteriostatic antibiotic. It works by binding to the 50S subunit of bacterial ribosomes, which inhibits protein synthesis and stops the growth and reproduction of bacteria. Because of structural differences, it specifically targets bacterial cells and does not affect the cells of mammals or birds.
Benefits:
Respiratory Disease: Highly effective against Chronic Respiratory Disease (CRD) in poultry and respiratory tract infections in cats and dogs (including Mycoplasma).
Soft Tissue & Skin: Treats foot rot in cattle, swine arthritis, and specific soft tissue infections in small pets.
Feed Efficiency: Promotes faster weight gain in pigs and cattle by supporting beneficial gut flora and reducing mild, subclinical pathogens.
Disease Prevention: Prevents liver abscesses in beef cattle and manages outbreaks in poultry flocks.
Cautions:
- Equine Warning: Tylosin must never be administered to horses or equines, as it can cause fatal reactions.
- Meat Withdrawal: Food-producing animals must observe specific withdrawal periods before slaughter (e.g., 21 days for cattle, 14 days for swine) to ensure meat tissue is free of residues.
- Overdosage: Accidental overdosing, particularly in baby pigs and calves, can result in shock or death
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